septibody product
Vaginal antiseptic solution based on 0.5% chlorhexidine
Septibody is an antiseptic product based on the antimicrobial substance chlorhexidine digluconate, which has been used for several decades in different countries of the world as an antiseptic suitable for skin and mucous membranes, and has obtained good clinical results in this field. This compound is included and registered in international pharmacopoeias such as BP, USP for use as an antiseptic for vaginal mucosa and birth canal.
Today, the problems and toxicities caused by iodine-containing antiseptics (povidone-iodine) for mother and baby or ineffective traditional methods have limited the use of vaginal antiseptic methods.
But Septibody uses the effective and confirmed chlorhexidine and having acidity according to the natural pH of the vaginal tissue.
(2.4 – 3.8) The presence of softeners and mild anti-inflammatory substances in its formulation is a practical and effective drug for controlling and preventing microbial infections of the female genital and urinary system, which does not have systemic absorption.
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Recommended clinical applications
Vaginal preparation before and after natural childbirth and cesarean section [1-5]
Washing the vagina with septibody as an antiseptic solution can be used to disinfect the vaginal environment in prenatal examinations and reduce the risk of rising infections in cesarean section, as well as to prevent further complications such as fever and endometritis.
Before and after vaginal surgery and surgery through the vagina [4,6,7]
Unlike iodine-containing products, which are not very effective in alkaline environments such as blood and secretions, Septibody products can create a suitable surgical environment for up to 90 minutes, and by creating an antimicrobial coating from 24 to 72 hours, for surgeries including puncture, IVF, hysterosalpingography, hysteroscopy. and provide…
In cases of PROM to prolong pregnancy [2,8]
One of the complications of vaginal infection of PROM, followed by premature delivery, is lung failure, LBW, and finally the increase in fetal death. In PROM, in addition to preventive measures such as rest, antibiotic use, and coronet injection for fetal lung maturation, vaginal washing with septibody product can be used to help eliminate pathogens and prolong pregnancy.
Helping to treat vaginal infections [3,4]
At the same time as taking oral or vaginal antibiotics, using an antiseptic antiseptic product to destroy the colony of pathogens and bring the appropriate pH to the vagina before using vaginal tablets and ointments can help treat the infection. In addition, the use of this product can prevent the long-term use of antibiotics.
Suitable for people with immune system deficiency [4]
In women with immune system defects, such as cancer patients, patients who are undergoing chemotherapy or long-term treatment with corticosteroids, in case of vaginitis, it is better to wash with a suitable vaginal antiseptic solution along with pills or local vaginal drugs. Use like Septibody.
Reduction of urinary infections (UTI) [3]
In cases of UTI, using septic antiseptic solution to disinfect the external environment of the vagina can help the treatment.
Reducing complications of iodine toxicity in mother and fetus [9]
The use of iodine for vaginal washing has disadvantages such as the inactivation of iodine-based products (povidone-iodine) in the presence of blood, the ability to absorb iodine in vaginal cavities due to non-keratin epithelium, abnormality in cardiac conduction, lactic acidosis, acute kidney failure, It is hypocalcemia. Also, these products have an alkaline pH, and in the acidic environment of the vagina, their antimicrobial power decreases significantly. Therefore, the use of vaginal antiseptic solution based on chlorhexidine as a suitable alternative can reduce the adverse effects of iodine on the mother and the fetus.
Reducing antibiotic resistance and recurrent infections [3]
The use of septibody product, due to the disinfection of the vaginal environment, while maintaining the normal pH of the vagina and preventing the disruption of its natural flora, reduces the risk of recurrent infections and reduces the need for antibiotics. So this can be very important in helping to reduce resistance to antibiotics.
Helping to treat post-surgical infections (SSI) [2,4,7,8,10]
According to WHO guidelines, chlorhexidine has persistent antimicrobial effects. Therefore, due to the presence of chlorhexidine in its formulation, Septibody has the ability to create an antimicrobial coating on the wound from a minimum of 24 to a maximum of 72 hours and help heal the wound after surgery.
Septibody features
Septibody is based on chlorhexidine digluconate, which is an antiseptic approved in all reputable pharmacopoeias of the world.
It has a pH corresponding to that of the vaginal mucosa, equivalent to 3.8 to 4.2.
Toxicity and sensitization effects for mother and baby have not been reported.
It has softening and moisturizing ingredients to better maintain the moisture of the vaginal tissue.
It has disposable and hygienic applicators and it is available in 5 packs of 140 ml single dose from pharmacies all over the country. It is also available in 500 ml packaging for clinical use.
It has lactic acid to adjust the pH and make the environment susceptible to the growth of natural vaginal lactobacilli.
It has a good effect on harmful bacteria and yeasts in the reproductive and urinary systems of women.
Product Specifications
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Color/Shape Pink solution
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pH 4.2 – 3.8
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Smell Pleasant smell
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Shelf life 24 months
Method of Use
Clinical method of vaginal washing and preparation:
Pour the required amount of septibody into the sterile set and then soak some sterile gauze in the solution. Then wash the external environment of the vagina first. After that, insert the speculum and wash from the cervix down. Repeat this several times.
How to use at home:
First, wash your hands well with soap and water and then remove the applicator and container containing the solution from the package. Connect the applicator to the container. Insert the nozzle of the applicator into the vagina and press gently until all the solution is drained.
Compounds
Chlorhexidine digluconate 0.5%, lactic acid, emollients, pH adjusting agents, color and deionized water
Irritability and sensitization study
Septibody product is non-stimulating and non-allergenic for the skin based on test results in accordance with the ISO 10993:2013 standard.
considerations
Considering that the healthy vaginal environment contains natural microflora and has the ability to self-clean, the use of septibody is recommended with the prescription of a specialist doctor and for health and therapeutic measures, therefore, the indiscriminate use and self-prescription of this medicine should be avoided. .
Warning
- The use of any applicators and implants in the genital and vaginal areas must be prescribed by a specialist doctor, so avoid using this product arbitrarily and indiscriminately.
- This product is only for washing and disinfecting the female reproductive system and should not be used to prevent pregnancy.
- This product is only for washing and disinfecting the female reproductive system and should not be used to prevent pregnancy.
- Keep out of the reach of children and uninformed people.
- Keep away from heat and direct sunlight.
- Avoid spraying this product into the eyes and ears.
- If you notice any symptoms such as burning, itching and allergic symptoms, stop using the solution and consult a doctor.
- Store at a temperature between 5 and 35 degrees Celsius.
Packing
5 pcs per box with applicator 140 ml volume
1 per box with applicator 250 ml volume
20 pieces per carton 500 ml volume
References
[1] Christian etal/AOGS 100 (2021) 694-703.
[2] Tewfik etal/Int. J. Curr. Microbial.App.Sci 4 (2015) 486-492.
[3] Stray-pedersen etal/Int. J. Antimicrobial Agents 12 (1999) 245-251.
[4] Lakhi etal/AJOG MFM 135 (2019) 1-8.
[5] Clinical Trials. gov Identifier: NCT03423147 (2023).
[6] Hill etal/Obstetrics & Gynecology 135 (2020) 20S.
[7] Rao etal/JMSCR 5 (2017) 20266-20273.
[8] Watanabe etal/J. Obstet. Gynaecol. Res. 24 (1998) 285-290.
[9] Kucuker etal/Pediatr Int. 65 (2023) 1-9.
[10] Dunyao etal/Int Wound J 21 (2023) 1-11.